Confirmatory Factor Analysis of the Analgesic Adverse Drug Event Measure

Area of Science:

• Pharmacovigilance
• Patient Safety
• Health Measurement

Background:

• Analgesic adverse drug events (ADEs) are common and impact patient outcomes.
• Measuring patient responses to analgesic ADEs is crucial for understanding their experiences.
• The Analgesic Adverse Drug Event Measure (AADEM) was developed to capture these responses.

Purpose of the Study:

• To confirm the construct validity of the Analgesic Adverse Drug Event Measure (AADEM).
• To validate the underlying factors of the AADEM: attributed ADE, consulted provider, sought care, and analgesic continuation/discontinuation.

Main Methods:

• Cross-sectional instrumentation design.
• Online survey administration of the AADEM to 332 adults reporting analgesic ADEs.
• Confirmatory factor analysis and reliability testing were performed.

Main Results:

• Adequate model fit was observed across all indexes.
• Low internal consistency for the full AADEM, but generally acceptable subscale consistency.
• Significant correlations between latent factors influenced reliability.

Conclusions:

• The study supported the construct validity of the AADEM.
• Advanced practice nurses and primary care providers can utilize the AADEM.
• The AADEM offers insights to help prevent future analgesic ADEs.