The Genetic Association of MMP-2 Gene Polymorphisms with the Susceptibility to Alzheimer's Disease
Lina Liu1, Luran Liu1, Yunting Lu1
1Department of Neurology, Science and Technology Innovation Park of the Fourth Affiliated Hospital of Harbin Medical University, 150028 Harbin, Heilongjiang, China.
Background:
A hospital-based case-control study was carried out to elucidate the association of Matrix metalloproteinase-2 (MMP-2) gene candidate polymorphisms with the susceptibility to Alzheimer's disease (AD) in the Chinese Han population.
Methods:
A total of 200 AD cases and an equal number of healthy controls were recruited to undergo genotyping of specific loci within the MMP-2 gene loci (rs243866, rs2285053, rs243865). Logistic regression analysis was applied to examine the association of the genotypes and alleles of MMP-2 gene polymorphisms with AD after adjusting clinical confounding factors.
Results:
Within AD group, a high proportion of rs243866 genotype carriers were found, and the difference remained significant despite adjusting for other clinical indicators. Among individuals with the rs243866 AA genotype and rs243865 TT genotype, the onset age of AD occurred at a younger age. Early-onset AD risk in rs243866 AA genotype carriers was 6.528 times higher than those in GG genotype carriers, and individuals with rs243865 TT genotype faced a 4.048-fold increased risk compared to those with CC genotype.
Conclusions:
MMP-2 gene rs243866 and rs243865 polymorphisms were closely associated with the onset age of AD. The presence of rs243866 AA genotype emerged as a crucial predictor of AD risk.
Insights
Matrix metalloproteinase-2 (MMP-2) gene polymorphisms rs243866 and rs243865 are linked to Alzheimer's disease (AD) onset age. The MMP-2 rs243866 AA genotype is a significant predictor of AD risk.
Area of Science:
- Genetics
- Neuroscience
- Molecular Biology
Background:
- Investigating genetic factors influencing Alzheimer's disease (AD) susceptibility.
- Focus on Matrix metalloproteinase-2 (MMP-2) gene polymorphisms in the Chinese Han population.
Purpose of the Study:
- To determine the association between MMP-2 gene polymorphisms and Alzheimer's disease risk.
- To explore the impact of specific MMP-2 gene loci on AD onset age.
Main Methods:
- Hospital-based case-control study involving 200 AD cases and 200 healthy controls.
- Genotyping of MMP-2 gene loci: rs243866, rs2285053, and rs243865.
- Logistic regression analysis to assess genotype and allele associations with AD, adjusting for clinical factors.
Main Results:
- Significant association found between MMP-2 gene polymorphisms and AD.
- The rs243866 AA genotype and rs243865 TT genotype were linked to younger AD onset age.
- Carriers of the rs243866 AA genotype had a 6.5-fold higher risk of early-onset AD; rs243865 TT carriers had a 4.0-fold increased risk.
Conclusions:
- MMP-2 gene polymorphisms rs243866 and rs243865 are closely associated with Alzheimer's disease onset age.
- The rs243866 AA genotype is a critical predictor for Alzheimer's disease risk.
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