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This summary is machine-generated.

Bleb-based cell migration, vital in health and disease, is less understood than other motility types. This review systematically explores its mechanisms, focusing on polarity, bleb dynamics, and membrane-cortex interactions.

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • Bleb-based migration is a fundamental cell motility process.
  • Its mechanisms are less understood compared to lamellipodium-based migration.
  • This process is crucial in physiological and pathological contexts.

Purpose of the Study:

  • To systematically review the mechanisms of bleb-based migration.
  • To highlight the establishment of front-rear polarity and bleb dynamics.
  • To discuss the role of plasma membrane-cortex interactions and force generation.

Main Methods:

  • Systematic literature review.
  • Analysis of physical and molecular mechanisms.
  • Emphasis on recent evidence and proposed regulatory roles.

Main Results:

  • Detailed overview of polarity establishment in bleb-based migration.
  • Characterization of distinct bleb formation, extension, and dynamics.
  • Evidence for plasma membrane-cortex interactions regulating blebbing.

Conclusions:

  • Bleb-based migration involves complex regulation of polarity and bleb dynamics.
  • Plasma membrane-cortex interactions are key regulators of blebbing behavior.
  • Understanding these mechanisms is critical for health and disease research.