Related Experiment Video

Updated: Jun 29, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
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Published on: May 18, 2017

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METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging

Yaobin Wang1,2,3, Yi Chen1,2,3, Hefang Xiao1,2,3

  • 1Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, China.

Cell Death Discovery
|March 28, 2024
PubMed
Summary

Methyltransferase-like 3 (METTL3) inhibits osteoblast aging, a key factor in senile osteoporosis. METTL3 stabilizes Hspa1a mRNA, offering a potential therapeutic target for osteoporosis.

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