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Published on: January 28, 2020
S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure
Jie Ma1,2, Yang Li1,2, Ping Li1
1Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Insights
Elevated S100A8/A9 protein levels predict heart failure after acute myocardial infarction. This biomarker offers superior prediction compared to traditional markers and shows a potential causal link.
Area of Science:
- Cardiology
- Biomarker Discovery
- Proteomics
Background:
- Heart failure is a common complication following acute myocardial infarction.
- Identifying reliable biomarkers for post-myocardial infarction heart failure is crucial for patient management.
Purpose of the Study:
- To identify and validate a novel biomarker for predicting heart failure after acute myocardial infarction.
- To assess the predictive performance of the identified biomarker against traditional risk factors.
Main Methods:
- Proteomic analysis was used to screen potential biomarkers in discovery and validation cohorts (1062 and 1043 patients, respectively).
- Observational study design to evaluate associations with in-hospital and long-term heart failure events.
- Mendelian randomization was employed to investigate the causal effect of the biomarker on heart failure.
Main Results:
- Elevated circulating S100A8/A9 levels were independently associated with heart failure in both discovery and validation cohorts.
- S100A8/A9 demonstrated superior predictive value compared to traditional biomarkers.
- Incorporating S100A8/A9 improved risk estimation when added to traditional risk factors.
Conclusions:
- S100A8/A9 is a significant predictor of heart failure post-acute myocardial infarction.
- S100A8/A9 may act as a causal mediator in the development of heart failure.
- This biomarker holds potential for enhanced risk stratification and management of patients post-myocardial infarction.
Abstract:
Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three independent cohorts using Mendelian randomization approach. Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction.
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