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Challenges in ageing persons with haemophilia
Michael Makris1, Riitta Lassila2, Megan Kennedy3
1School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Summary
As treatments for inherited bleeding disorders improve, longer lifespans bring new challenges like thrombosis and persistent musculoskeletal pain. Managing these complex issues requires a collaborative, person-centered approach for optimal quality of life.
Area of Science:
- Geriatrics
- Hematology
- Pharmacology
Background:
- Improved treatments for inherited bleeding disorders are increasing patient life expectancy.
- This demographic shift introduces age-related health concerns, including thrombosis and chronic pain, into the bleeding disorder population.
Purpose of the Study:
- To review the complexities of managing thrombosis in individuals with inherited bleeding disorders.
- To highlight the ongoing challenges of musculoskeletal pain in aging patients with hemophilia and comorbidities.
Main Methods:
- Literature review on thrombosis risk associated with high clotting factor levels and non-factor therapies.
- Analysis of pain management strategies for older adults with hemophilia and multiple comorbidities.
Main Results:
- A recognized association exists between low clotting factor levels and bleeding risk, and between high levels/certain therapies and thrombotic risk.
- Thrombosis management in this population is complex but achievable with modern treatments and collaborative decision-making.
- Musculoskeletal pain remains a significant issue in aging individuals with hemophilia, impacting quality of life.
Conclusions:
- Effective management of thrombosis in inherited bleeding disorders requires a multidisciplinary approach involving healthcare professionals and patients.
- A person-centered, holistic, and multidisciplinary strategy is crucial for managing chronic pain and optimizing function in older adults with hemophilia and comorbidities.
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