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Antibiotic Selection

Antibiotic Selection

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Related Experiment Video

Updated: Jun 29, 2025

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy.

David Hourigan^1,2, Ewelina Stefanovic^1,3, Colin Hill^1,2

¹APC Microbiome Ireland, Biosciences Institute, Biosciences Research Institute, College Rd, University College, Cork, Ireland.

BMC Microbiology

|March 28, 2024

Summary

Vancomycin-resistant enterococci (VRE) are dangerous pathogens causing severe infections. Genomics reveals VRE

Keywords:

Antimicrobial resistance (AMR)Bacteriocins Bacteriophage Colonisation-resistance Enterococcus Synergy

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Last Updated: Jun 29, 2025

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

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Published on: December 23, 2022

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

Microbiology
Genomics
Infectious Diseases

Background:

Vancomycin-resistant enterococci (VRE) are significant opportunistic pathogens responsible for serious infections like urinary tract infections and endocarditis.
VRE, primarily Enterococcus faecium and E. faecalis, colonize the gastrointestinal tract and can lead to systemic dissemination.
Hospital-associated VRE strains exhibit increased mobile genetic elements, numerous antibiotic resistance genes, and often lack functional CRISPR-Cas systems.

Purpose of the Study:

To review current knowledge on VRE genomics.
To discuss state-of-the-art therapeutic advances against VRE infections.

Main Methods:

Genomic analysis of VRE isolates.
Comparative genomics to understand dissemination routes.
Literature review of therapeutic strategies.

Main Results:

Genomic studies highlight VRE characteristics including increased mobile genetic elements and antibiotic resistance genes.
Comparative genomics aids in understanding VRE transmission pathways among patients and healthcare workers.
Declining antibiotic efficacy necessitates novel control measures.

Conclusions:

New strategies are crucial for controlling VRE infections due to diminishing antibiotic effectiveness.
Potential approaches include antibiotic combinations, enhancing gut microbiota resistance, and utilizing non-antibiotic agents like bacteriophages or bacteriocins.