Related Experiment Video
Updated: Jun 29, 2025

Guidelines for Elective Pediatric Fiberoptic Intubation
Published on: January 17, 2011
Pre-Admission Oral Clonidine to Reduce Severe Pre-Operative Anxiety in Pediatric Patients with Behavioral Disorders:
Nicole Verdecchia1, Ryan Nelson1, Shante White1
1Department of Anesthesiology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
Insights
Pre-admission oral clonidine effectively reduced preoperative anxiety in pediatric patients, facilitating hospital entry and improving family cooperation. A transient side effect of hypotension was noted, with no lasting complications.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
Background:
- Preoperative anxiety in children can lead to behavioral issues, post-traumatic stress, and increased pain management needs.
- Managing anxiety in pediatric patients, particularly those with behavioral challenges, is crucial for a smooth hospital admission.
Observation:
- A case series involving six pediatric patients explored the use of pre-admission oral clonidine.
- This intervention aimed to mitigate anxiety and facilitate the hospital admission process for children and their families.
Findings:
- All six patients successfully entered the hospital without difficulty following pre-admission clonidine administration.
- Families reported subjective improvements in anxiety levels and cooperation compared to prior experiences.
- Transient intraoperative hypotension was observed as a side effect, resolving without long-term consequences.
Implications:
- Pre-admission oral clonidine may be a valuable tool for managing pediatric preoperative anxiety.
- This approach can enhance patient and family experience during hospital admissions.
- Further research into optimal dosing and patient selection for oral clonidine is warranted.
Abstract:
Controlling preoperative anxiety is necessary in pediatric patients to avoid adverse effects such as emergence delirium, behavioral problems, post-traumatic stress disorder, anxiety prior to future procedures, and increased analgesic doses in the recovery room. Some patients, especially ones with behavioral issues, have a difficult time arriving at the hospital. Medications given at home can be helpful. We describe a case series of six patients who received pre-admission oral clonidine prior to arrival to the hospital. The patients were all able to enter the hospital without difficulty and the families reported less anxiety and more cooperation subjectively compared with previous experiences. Transient intraoperative hypotension was a side effect of oral clonidine, with no long-term sequelae.
Related Concept Videos
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Parenteral Anesthetics: Overview
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Anxiolytic Drugs: Benzodiazepines and Buspirone
Drug Delivery: Enteral Route

