Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EpiATLAS - a reference for human epigenomic research.

bioRxiv : the preprint server for biology·2026
Same author

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B-BCL6 Regulatory Circuit in Burkitt Lymphoma.

International journal of cancer·2026
Same author

Relevance of Epstein-Barr Virus (EBV) miRNAs in EBV-Infected B Cells and B-Cell Lymphomas.

Cancers·2026
Same author

Author Correction: Whole-body CD8<sup>+</sup> T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study.

Nature communications·2026
Same author

Impact of rituximab maintenance on survival in patients with mantle cell lymphoma: a population-based cohort study.

Blood advances·2026
Same author

Whole-body CD8<sup>+</sup> T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study.

Nature communications·2025

Related Experiment Video

Updated: Jun 29, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.7K

Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis.

Yujia Pan1, Roza Cengiz1, Joost Kluiver1

  • 1Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 RB Groningen, The Netherlands.

Cancers
|March 28, 2024
PubMed
Summary

This review details microRNA (miRNA) interactions critical for classical Hodgkin lymphoma (cHL) pathogenesis. It highlights specific miRNAs and their target genes involved in B-cell origin, immune evasion, and tumor growth.

Keywords:
classical Hodgkin lymphomagrowth supportimmune evasionloss of B-cell phenotypemiRNA

More Related Videos

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

6.2K
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

6.8K

Related Experiment Videos

Last Updated: Jun 29, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.7K
Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

6.2K
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

6.8K

Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • Classical Hodgkin lymphoma (cHL) is a B-cell malignancy characterized by Hodgkin and Reed-Sternberg (HRS) cells.
  • MicroRNAs (miRNAs) are key regulators of gene expression implicated in various cancers.

Purpose of the Study:

  • To review known miRNA-target gene interactions relevant to cHL pathogenesis.
  • To identify potential regulatory roles of miRNAs in B-cell phenotype loss, immune evasion, and growth support in cHL.
  • To establish a cHL-specific miRNA signature.

Main Methods:

  • Comprehensive review of existing literature on validated miRNA-target gene interactions.
  • Analysis of miRNA profiling studies to generate a cHL-specific signature.
  • Focus on genes involved in B-cell phenotype, immune evasion, and growth support.

Main Results:

  • Identified several miRNAs (e.g., miR-155-5p, miR-148a-3p, miR-181a-5p) with critical roles in cHL.
  • These miRNAs target genes such as PU.1, ETS1, HLA-I, PD-L1, and NF-κB components.
  • A cHL-specific miRNA signature was generated.

Conclusions:

  • miRNA-target gene interactions play significant roles in cHL pathogenesis.
  • Selected miRNAs and their targets offer potential therapeutic targets and diagnostic biomarkers.
  • This review provides a foundation for future functional studies on miRNAs in cHL.