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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer Therapies02:49

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Tumor Immunotherapy

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Updated: Jun 9, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

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Published on: December 1, 2013

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CD44 in Bladder Cancer.

Jason Duex1, Dan Theodorescu1,2,3

  • 1Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USA.

Cancers
|March 28, 2024
PubMed
Summary
This summary is machine-generated.

The glycoprotein CD44, a key player in cell functions, is implicated in cancer progression and metastasis. Its diverse roles make CD44 a promising therapeutic target, particularly for bladder cancer treatment.

Keywords:
CD44androgen receptorbladder cancerglycosylationhyaluronic acid

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The glycoprotein CD44 exhibits numerous isoforms and glycosylation patterns.
  • CD44 is involved in a wide array of normal and pathological cellular processes.
  • Cancer progression and metastasis are among the cellular processes influenced by CD44.

Purpose of the Study:

  • To highlight the significance of CD44 in cellular functions.
  • To underscore the role of CD44 in cancer, specifically metastasis.
  • To establish CD44 as a potential therapeutic target in oncology.

Main Methods:

  • Literature review on CD44 structure and function.
  • Analysis of CD44's involvement in cellular signaling pathways.
  • Examination of CD44's role in tumor development and spread.

Main Results:

  • CD44's isoforms and glycosylation variations contribute to its diverse cellular functions.
  • CD44 plays a critical role in cancer progression and metastasis.
  • The multifaceted nature of CD44 presents it as a viable therapeutic target.

Conclusions:

  • CD44's involvement in numerous cellular processes, including cancer, is well-established.
  • Targeting CD44 offers a promising strategy for cancer therapy.
  • Bladder cancer is a key area where CD44-targeted therapies could be beneficial.