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Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation

Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation

Theofanis Vavilis ^1,2, Maria Louiza Petre ³, Giannis Vatsellas ⁴, Alexandra Ainatzoglou ³, Eleni Stamoula ³, Athanasios Sachinidis ⁵, Malamatenia Lamprinou ⁶, Ioannis Dardalas ⁶, Ioannis N Vamvakaris ⁷, Ioannis Gkiozos ⁸, Konstantinos N Syrigos ⁸, Athanasios K Anagnostopoulos ³

Theofanis Vavilis ^1,2, Maria Louiza Petre ³, Giannis Vatsellas ⁴

¹Department of Dentistry, European University Cyprus, Nicosia 2404, Cyprus.
²Laboratory of Biology and Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
³Department of Biotechnology, Centre of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
⁴Greek Genome Centre, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
⁵4th Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
⁶Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
⁷Pathology Department, "Sotiria" Hospital, 11527 Athens, Greece.
⁸Third Department of Internal Medicine, "Sotiria" Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.

⁰Department of Dentistry, European University Cyprus, Nicosia 2404, Cyprus.

Cancers +

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March 28, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Proteogenomics integrates genomic and proteomic data to advance lung cancer research. This approach reveals molecular insights, identifies predictive biomarkers, and guides personalized medicine for improved patient outcomes.

Area Of Science

Oncology
Genomics
Proteomics
Proteogenomics

Background

Lung cancer remains a leading cause of global mortality, with genomic studies revealing some, but not all, underlying molecular mechanisms.
Proteogenomics, the integration of genomic and proteomic profiling, offers a novel dimension for understanding lung cancer complexities.

Purpose Of The Study

To review proteogenomic approaches applied to lung cancer research.
To explore how understanding proteogenomic features can lead to significant clinical benefits.
To synthesize landmark studies in lung cancer proteogenomics for personalized medicine.

Main Methods

Systematic review of existing literature.
Focus on studies detailing molecular attributes, tumor biomarkers, and oncogenesis hallmarks.

Main Results

Proteogenomics is expected to bridge critical knowledge gaps and facilitate the discovery of new therapeutic strategies.
Genomic profiling identifies driver mutations, while downstream analysis reveals variability in transcript-protein correlations.
Proteogenomic characterization of major histological subtypes yields diverse predictive markers and potential drug targets.

Conclusions

Proteogenomics is crucial for advancing personalized medicine in lung cancer.
This integrated approach enhances our ability to combat lung cancer through tailored treatments.

Keywords:

NSCLC SCLC aberrant protein expression genetic alterations lung cancer multi-omics proteogenomics

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