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The Perspectives of Platelet Proteomics in Health and Disease
Preeti Kumari Chaudhary1, Sachin Upadhayaya1, Sanggu Kim1
1Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Insights
Platelet proteomics can identify disease-specific biomarkers for better cardiovascular and cancer diagnoses. This research explores using platelet proteomic data for personalized medicine and novel therapeutic targets.
Area of Science:
- Biochemistry
- Proteomics
- Oncology
- Cardiology
Background:
- Cardiovascular thromboembolic diseases and cancer are leading global causes of death.
- Current diagnostic markers lack disease specificity, hindering individualized medicine.
- Platelets play a crucial role in both cancer and cardiovascular diseases.
Purpose of the Study:
- To review the potential of platelet proteomic research for identifying novel biomarkers.
- To explore the application of platelet proteomics in personalized and precision medicine.
- To identify new diagnostic and pharmaceutical targets for cardiovascular and cancer diseases.
Main Methods:
- Analysis of peptide and protein subsets in platelets from patients and healthy individuals.
- Focused platelet proteomics for quantifying disease-specific biomarkers.
- Review of existing literature on platelet proteomic research and its applications.
Main Results:
- Focused platelet proteomics enables the quantification of disease-specific biomarkers in humans.
- Platelet proteomic analysis reveals differences between healthy and diseased states.
- The study highlights the potential for discovering novel diagnostic and therapeutic targets.
Conclusions:
- Platelet proteomic research holds significant promise for advancing the diagnosis and treatment of cardiovascular and cancer diseases.
- Accurate platelet proteomic analysis is essential for comprehending proteome variations in personalized medicine.
- This approach can lead to the development of novel diagnostic tools and pharmaceutical targets for improved patient outcomes.
Abstract:
Cardiovascular thromboembolic diseases and cancer continue to be a leading cause of death and disability worldwide. Therefore, it is crucial to advance their diagnoses and treatment in the context of individualized medicine. However, the disease specificity of the currently available markers is limited. Based on analyses of a subset of peptides and matching proteins in disease vs. healthy platelets, scientists have recently shown that focused platelet proteomics enables the quantification of disease-specific biomarkers in humans. In this review, we explored the potential of accurate platelet proteomic research, which is required to identify novel diagnostic and pharmaceutical targets by comprehending the proteome variety of healthy individuals and patients for personalized and precision medicine.
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