Ceruloplasmin, Catalase and Creatinine Concentrations Are Independently Associated with All-Cause Mortality in...

Area of Science:

• Cardiology
• Biochemistry
• Biomarkers

Background:

• The role of oxidative and antioxidative system imbalances in advanced heart failure (HF) remains incompletely understood.
• Identifying reliable prognostic factors for one-year mortality in advanced HF is crucial for patient management.

Purpose of the Study:

• To investigate factors associated with one-year mortality in advanced HF patients.
• To specifically assess the prognostic value of oxidative/antioxidative balance parameters.

Main Methods:

• Analysis of 85 advanced heart failure patients undergoing right heart catheterization.
• Measurement of oxidative/antioxidative markers, including ceruloplasmin and catalase, from coronary sinus blood.
• Multivariable logistic regression and ROC analysis to determine associations with one-year mortality.

Main Results:

• One-year mortality rate was 40%.
• Lower ceruloplasmin and catalase levels in coronary sinus blood, and higher creatinine levels in peripheral blood were independently associated with one-year mortality.
• Catalase and ceruloplasmin demonstrated excellent prognostic power (AUC > 0.92), while creatinine showed acceptable power (AUC > 0.76).

Conclusions:

• Imbalances in the oxidative/antioxidative system, specifically lower ceruloplasmin and catalase, are significant predictors of mortality in advanced HF.
• Higher creatinine levels also independently predict mortality.
• These biomarkers can effectively distinguish one-year survivors from non-survivors in advanced HF populations.