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Non-Coding RNAs: Novel Regulators of Macrophage Homeostasis in Ocular Vascular Diseases

Qiuyang Zhang1,2, Qing Liu1,2, Siguo Feng1,2

  • 1Affiliated Eye Hospital, Nanjing Medical University, Nanjing 210029, China.

Biomolecules
|March 28, 2024
PubMed

Insights

Dysfunctional macrophages contribute to ocular neovascularization. Non-coding RNAs (ncRNAs) regulate macrophage homeostasis, offering potential therapeutic targets for vision-threatening vascular diseases.

Area of Science:

  • Ophthalmology
  • Immunology
  • Molecular Biology

Background:

  • Ocular neovascularization significantly impacts vision and quality of life.
  • The precise mechanisms driving ocular neovascularization remain unclear.
  • Macrophages are crucial innate immune cells involved in inflammation and tissue repair.

Purpose of the Study:

  • To review the regulatory roles of non-coding RNAs (ncRNAs) in macrophage homeostasis.
  • To explore the involvement of ncRNA-mediated macrophage dysfunction in ocular vascular diseases.

Main Methods:

  • Literature review of existing studies.
  • Analysis of research on ncRNAs and macrophage biology.
  • Synthesis of findings related to ocular vascular conditions.

Main Results:

  • Macrophage homeostasis is critical for preventing ocular vascular diseases.
  • Non-coding RNAs (ncRNAs) are key regulators of macrophage function and homeostasis.
  • Aberrant ncRNA expression is implicated in the pathogenesis of ocular neovascularization.

Conclusions:

  • Dysregulation of ncRNAs impacts macrophage homeostasis, contributing to ocular neovascularization.
  • Targeting ncRNAs offers a potential strategy for treating ocular vascular diseases.
  • Further research into ncRNA-macrophage interactions is warranted for therapeutic development.
Keywords:
macrophagenon-coding RNApathological angiogenesis

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