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Evaluation of the Levels of Selected Cytokines and Their Possible Influence on the Development of Cardiovascular and
Anita Stanjek-Cichoracka1,2, Jacek T Niedziela3,4, Anna Łaszewska2
1Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.
Medicina (Kaunas, Lithuania)
|March 28, 2024
Summary
This study found no direct link between cytokine levels and cardiovascular/pulmonary issues post-COVID-19. However, elevated levels of certain cytokines in survivors warrant further monitoring for potential long-term health concerns.
Area of Science:
- Immunology
- Cardiology
- Pulmonology
- Infectious Diseases
Background:
- COVID-19 survivors may develop cardiovascular and pulmonary complications.
- Cytokines play a role in inflammatory and disease processes.
- Understanding post-COVID-19 immune responses is crucial for managing long-term health.
Purpose of the Study:
- To evaluate selected cytokine levels in COVID-19 survivors.
- To investigate the influence of these cytokines on cardiovascular and pulmonary complications.
- To assess potential correlations in patients hospitalized at the Silesian Centre for Heart Disease.
Main Methods:
- Analysis of 76 COVID-19 survivors from the SILCOVID-19 database.
- Measurement of 30 serum cytokines using Luminex100 platform and Milliplex MAP kit.
- Data collected a median of 102 days post-symptom onset.
Main Results:
- No significant differences in most cytokine levels were found between patients with or without lung/cardiac abnormalities.
- Cytokine concentrations did not significantly differ based on gender, age, comorbidities, or psychological disorders.
- Elevated levels of platelet-derived growth factor-AA (PDGF-AA), monocyte chemoattractant protein-1 (MCP-1), monokine-induced gamma interferon (MIG), and vascular endothelial growth factor-A (VEGF-A) were observed.
Conclusions:
- No direct association was found between the studied cytokines and the incidence of cardiovascular/pulmonary complications in COVID-19 survivors.
- High levels of cytokines like PDGF-AA, VEGF, MIG, IP10 (lung disease relevance), and MCP-1 (cardiovascular disease relevance) are concerning in this cohort.
- Continued monitoring of cytokine levels and diagnostic imaging is recommended for early detection and management of potential abnormalities in COVID-19 survivors.
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