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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Diagnostic Challenges in Inflammatory Choroidal Neovascularization.

Izabella Karska-Basta1,2, Weronika Pociej-Marciak1,2, Katarzyna Żuber-Łaskawiec1,2

  • 1Chair of Ophthalmology, Faculty of Medicine, Medical College, Jagiellonian University, Kopernika Str. 38, 31-501 Krakow, Poland.

Medicina (Kaunas, Lithuania)
|March 28, 2024
PubMed
Summary

Inflammatory choroidal neovascularization (iCNV) arises from inflammation impacting the RPE-Bruch's membrane complex, potentially leading to vision loss. Advanced imaging aids in diagnosing this challenging condition, though further research is needed.

Keywords:
fluorescein angiographyindocyanine green angiographyinflammatory choroidal neovascularizationmultimodal imagingnear-infrared autofluorescenceoptical coherence tomographyoptical coherence tomography angiographyuveitis

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Area of Science:

  • Ophthalmology
  • Immunology
  • Vascular Biology

Background:

  • Inflammation is a critical factor in choroidal neovascularization (CNV) development.
  • Inflammatory choroidal neovascularization (iCNV) is a rare but serious complication of infectious and non-infectious uveitis.
  • iCNV pathogenesis is thought to mirror wet age-related macular degeneration, involving hypoxia and growth factors.

Purpose of the Study:

  • To explore the role of inflammation in choroidal neovascularization.
  • To understand the pathogenesis of inflammatory choroidal neovascularization (iCNV).
  • To highlight the diagnostic challenges and advancements in iCNV detection.

Main Methods:

  • Review of existing literature on iCNV and related conditions.
  • Discussion of proposed pathogenic mechanisms including hypoxia and mediator release.
  • Emphasis on the utility of multimodal imaging, including optical coherence tomography (OCT) and OCT angiography.

Main Results:

  • Inflammation directly affecting the RPE-Bruch's membrane complex initiates iCNV.
  • Hypoxia and mediators like VEGF contribute to neovascularization in uveitis.
  • Distinguishing iCNV from other inflammatory lesions is diagnostically challenging.
  • OCT and OCT angiography show promise in aiding iCNV diagnosis.

Conclusions:

  • iCNV development is linked to inflammatory processes and hypoxia.
  • Accurate diagnosis of iCNV can be difficult, especially differentiating from inflammatory choroiditis.
  • Modern imaging techniques like OCT and OCT angiography offer improved diagnostic capabilities.
  • Further studies are required to fully establish the role of advanced imaging in iCNV management.