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Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders
Angelika Pointner1, Ulrike D B Krammer1, Elena Tomeva2
1Department of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
Life (Basel, Switzerland)
|March 28, 2024
Summary
MicroRNAs (miRNAs) in blood reflect diet, lifestyle, and sex. Specific miRNAs indicate metabolic health, inflammation, and disease risk, showing potential for personalized medicine.
Area of Science:
- Biochemistry
- Genetics
- Personalized Medicine
Background:
- Diet and lifestyle significantly impact health.
- MicroRNAs (miRNAs) are crucial regulators in health and disease.
- Understanding miRNA roles can advance personalized healthcare.
Purpose of the Study:
- To investigate circulating miRNAs as biomarkers for physiological characteristics.
- To explore the influence of diet and lifestyle on miRNA profiles.
- To identify sex-specific miRNA expressions related to health and disease.
Main Methods:
- Analysis of capillary blood samples from 305 participants.
- Correlation of miRNA expression with dietary patterns, lifestyle factors (smoking), and physiological characteristics.
- Identification of specific miRNA associations with inflammation, metabolic diseases, and sex differences.
Main Results:
- miR-155 linked to metabolic diseases and aging.
- Dietary patterns (vegetables, fruits, whole grains) correlated with specific anti-inflammatory miRNAs (miR-let-7a, miR-328) and reduced pro-inflammatory miR-21.
- Smoking associated with decreased miR-142; sex-biased expression observed, with miR-151a upregulated in females and miR-155 in aging females.
Conclusions:
- Circulating miRNA profiles are significantly influenced by lifestyle, nutrition, and sex.
- miRNAs show promise as biomarkers for personalized medicine.
- Tailoring healthcare based on individual miRNA profiles is a potential future direction.

