Circulating microRNAs in Cancer: A 5-Year Update with a Focus on Breast and Lung Cancers
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View abstract on PubMed
Summary
This summary is machine-generated.Circulating microRNAs (c-miRNAs) show promise in cancer research, particularly for breast and lung cancers. This review highlights their role in early detection, treatment resistance, and recurrence risk.
Area Of Science
- Oncology
- Molecular Biology
- Biochemistry
Background
- Circulating microRNAs (c-miRNAs) are non-coding RNAs in bodily fluids with significant prognostic potential in cancer.
- Recent research (2018-2023) highlights c-miRNAs' evolving role in understanding cancer biology and progression.
Purpose Of The Study
- To review the latest research on c-miRNAs in cancer, focusing on highly prevalent cancers like breast cancer (BC) and lung cancer (LC).
- To identify current research trends and insights regarding c-miRNAs in oncology.
Main Methods
- A narrative review of over 150 papers published on PubMed between 2018 and 2023 concerning c-miRNAs and cancer.
- Focused analysis on studies related to breast cancer and lung cancer, examining specific deregulated c-miRNAs like miR-21 and miR-145.
Main Results
- Breast cancer and lung cancer are the most frequently studied cancers in relation to c-miRNAs.
- c-miRNAs demonstrate effectiveness in key cancer research areas: early detection, therapeutic resistance, recurrence risk assessment, and novel detection platforms.
- miR-21 and miR-145 are frequently identified as deregulated in both breast and lung cancer studies.
Conclusions
- Circulating microRNAs remain a dynamic and significant area of oncologic research.
- Blood is the primary biological matrix investigated for c-miRNA analysis in cancer.
- c-miRNAs offer valuable insights into cancer detection, treatment, and prognosis, especially in breast and lung malignancies.
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