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Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation

Kishu Ranjan1, Chandramani Pathak2

  • 1Department of Pathology, School of Medicine, Yale University, New Haven, CT 06511, USA.

International Journal of Molecular Sciences
|March 28, 2024
PubMed

Insights

Fas-associated death domain (FADD) protein regulates programmed cell death and inflammation. Its cellular localization and signaling pathways are crucial for cell survival, proliferation, and immune responses.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Immunology

Background:

  • Fas-associated death domain (FADD) is an adaptor protein central to apoptosis signaling.
  • FADD mediates signals from death receptors to caspases, initiating programmed cell death.
  • Beyond apoptosis, FADD influences autophagy, proliferation, necroptosis, and senescence.

Purpose of the Study:

  • To review the diverse roles of FADD in cellular processes.
  • To analyze FADD's regulation of programmed cell death and inflammation.
  • To highlight the importance of FADD's spatiotemporal control.

Main Methods:

  • Literature review and analysis of FADD's molecular mechanisms.
  • Examination of FADD's involvement in various signaling pathways.
  • Discussion of FADD's role in cellular homeostasis and immune response.

Main Results:

  • FADD's critical role in transducing apoptotic signals.
  • FADD's involvement in diverse cellular functions including autophagy and proliferation.
  • FADD's significance in regulating inflammatory signaling and cellular homeostasis.
  • Spatiotemporal regulation of FADD is key to its diverse functions.

Conclusions:

  • FADD is a versatile protein regulating both cell death and survival pathways.
  • Understanding FADD's cellular dynamics is essential for comprehending its role in health and disease.
  • FADD acts as a crucial link between cell death, proliferation, and inflammatory signaling.
Keywords:
FADDNF-κBRIP kinasesapoptosisautophagycancerinflammationtherapy

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