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Flow Cytometry Analysis in Breast Implant-Associated Anaplastic Large Cell Lymphoma: Three Case Reports
Veronica Davanzo1, Alessandra Falda2, Paola Fogar2
1Laboratory Medicine Unit, Biomedical Sciences Department-DSB, University of Padova, 35128 Padova, Italy.
Diagnosing Breast Implant-Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is challenging. A new fixative preserves CD30 expression on cells for up to 72 hours, aiding diagnosis via flow cytometry.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Breast Implant-Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare malignancy requiring accurate diagnosis.
- Current diagnostic guidelines recommend an integrated approach including cell morphology, CD30 immunohistochemistry (IHC), and flow cytometry (FCM).
- Distinguishing rare neoplastic cells from reactive cells can be challenging in cytopathology and IHC.
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