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Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and
Guangling Yin1,2, Chunxing Pan1, Hong Liu3
1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Abstract:
Oxyresveratrol is one of the active ingredients derived from mulberry branch with strong anti-inflammatory bioactivity. In this research, we want to explore if oxyresveratrol can improve cognitive impairments and episodic-like memory and its mechanism. In LPS-induced BV-2 cells, 25 μM OXY can significantly inhibit the expression of NO and alter the M1/M2 polarization by regulating M1/M2 phenotype makers. In vivo, OXY (50, 100 mg/kg) significantly reversed cognitive impairments and alleviated neuronal injuries caused by neuroinflammation. According to network pharmacology analysis, OXY alleviated neuroinflammation via the PI3K-Akt pathway. In general, the research revealed that OXY can improve cognitive impairments and episodic-like memory through alleviating LPS-induced neuroinflammation and regulating the PI3K-Akt signaling pathway.
Insights
Oxyresveratrol (OXY) improves cognitive impairments and memory by reducing neuroinflammation. This compound alleviates neuronal damage and regulates the PI3K-Akt pathway, offering potential therapeutic benefits.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Oxyresveratrol (OXY), a mulberry-derived compound, exhibits anti-inflammatory properties.
- Neuroinflammation is a key factor in cognitive impairments and memory deficits.
Purpose of the Study:
- To investigate the effects of OXY on cognitive impairments and episodic-like memory.
- To elucidate the underlying mechanisms of OXY's action, particularly its impact on neuroinflammation.
Main Methods:
- In vitro: LPS-induced BV-2 cells were used to assess NO expression and M1/M2 polarization.
- In vivo: Cognitive function and neuronal injury were evaluated in animal models treated with OXY.
- Network pharmacology analysis was employed to identify key signaling pathways.
Main Results:
- OXY (25 μM) significantly inhibited nitric oxide (NO) production in BV-2 cells.
- OXY treatment altered M1/M2 polarization in microglia by regulating phenotype markers.
- In vivo, OXY (50, 100 mg/kg) reversed cognitive deficits and reduced neuroinflammation-induced neuronal injury.
- Network pharmacology identified the PI3K-Akt pathway as crucial for OXY's anti-neuroinflammatory effects.
Conclusions:
- Oxyresveratrol effectively improves cognitive impairments and episodic-like memory.
- OXY alleviates LPS-induced neuroinflammation and protects against neuronal injury.
- The PI3K-Akt signaling pathway is a key mediator of OXY's beneficial effects on cognition and neuroinflammation.
