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Updated: Jun 29, 2025

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Published on: March 12, 2015
Biocatalytic Synthesis of Coumarin S-Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing
Nastassja Burrini1, Arnaud Pâris1, Guillaume Collet2
1Institut de Chimie Organique et Analytique, University of Orléans CNRS UMR7311, F-45067 Orléans, France.
Abstract:
This study unveils an innovative method for synthesizing coumarin S-glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the synthesized compounds exhibited no cytotoxicity across various human cell lines. This research presents a promising avenue for the development of coumarin S-glycosides, paving the way for their application in diverse biomedical research areas.
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