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The Association of Body Composition Parameters Measured by Computed Tomography with Cancer Stage, Prognosis, and Survival in Patients with Renal Cell Carcinoma

  • 0Department of Radiology, Bursa Yuksek Ihtisas Training and Research Hospital, Mimar Sinan Mah. Polis Okulu Karsisi, Emniyet Cad. 16310 Yildirim, Bursa, Turkey.
Current Medical Imaging +

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March 28, 2024

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March 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative body composition, particularly the subcutaneous adipose tissue to skeletal muscle area ratio, is linked to survival and recovery in renal cell carcinoma patients. This ratio can predict mortality risk and aid clinical decision-making.

Area Of Science

  • Oncology
  • Radiology
  • Body Composition Analysis

Background

  • Renal cell carcinoma (RCC) treatment outcomes are influenced by patient factors.
  • Preoperative assessment of body composition may offer prognostic insights.

Purpose Of The Study

  • To investigate the association between preoperative body composition parameters and renal cell carcinoma (RCC) stage.
  • To evaluate the relationship between body composition and postoperative hospitalization duration and survival in RCC patients.

Main Methods

  • Retrospective analysis of 104 RCC patients undergoing surgery (2019-2023).
  • Computed tomography (CT) scans used to measure visceral adipose tissue, subcutaneous adipose tissue, total adipose tissue, and skeletal muscle area.
  • Calculation of various body composition parameter ratios.

Main Results

  • Significant correlations found between skeletal muscle area, total adipose tissue/skeletal muscle area ratio, and survival time in deceased patients.
  • Total adipose tissue showed a strong correlation with survival (r=0.704, p<0.001).
  • Subcutaneous adipose tissue/skeletal muscle area ratio emerged as an independent mortality risk factor, with a ratio ≤0.98 increasing mortality risk ~16-fold.

Conclusions

  • Preoperative body composition parameters, measurable via CT, correlate with mortality and postoperative recovery in RCC patients.
  • The subcutaneous adipose tissue/skeletal muscle area ratio is a valuable predictor of mortality risk.
  • These findings can guide clinicians in anticipating patient outcomes and potential treatment challenges.

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