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Updated: Aug 6, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Left ventricular function assessment including or excluding trabeculations in left ventricular non-compaction, a

Jean-Pierre Laissy1,2, Ahmed Ben Driss1,2,3

  • 1Departments of Radiology, Bichat University Hospital AP-HP, Paris, France.

Quantitative Imaging in Medicine and Surgery
|March 28, 2024
PubMed

Insights

Measuring left ventricular ejection fraction with and without trabeculations using cine magnetic resonance imaging (cineMR) helps differentiate left ventricular non-compaction (LVNC) from normal variants. This functional assessment aids in diagnosing LVNC.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Left ventricular non-compaction (LVNC) diagnosis often underestimates its morphological spectrum.
  • Functional assessment of compact myocardium and hypertrabeculations is crucial for understanding LVNC disease.

Purpose of the Study:

  • To evaluate if measuring left ventricular (LV) volume, mass, and ejection fraction (LVEF) with and without trabeculation inclusion on cine magnetic resonance (cineMR) can aid in diagnosing LVNC.
  • To compare these measurements in LVNC patients versus normal individuals with excess myocardial trabeculations.

Main Methods:

  • Retrospective single-center MRI study of 67 patients (30 LVNC, 16 controls) with hypertrabeculations.
  • LV volumes, mass, and LVEF measured with and without trabeculation inclusion using cineMR and CVI42 software.
  • Functional parameters compared using statistical tests; reproducibility assessed with Bland-Altman analysis.

Main Results:

  • Excluding trabeculations, LVEF was normal in both groups.
  • Including trabeculations, LVEF increased by 9.8% in LVNC and decreased by 10.9% in controls (P<0.0001).
  • Myocardial mass remained stable in LVNC but significantly decreased in controls when trabeculations were included.

Conclusions:

  • LVEF measurements differ significantly between LVNC patients and controls depending on trabeculation inclusion.
  • These distinctive measurements can serve as an adjunctive clinical tool for confirming LVNC diagnosis.
Abstract

Keywords:
Myocardiumcardiac magnetic resonance (CMR)left ventricular non-compaction cardiomyopathy (LVNC cardiomyopathy)trabeculation

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