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Pigs: Large Animal Preclinical Cancer Models
Kirtan Joshi1,2,3, Tejas Katam3, Akshata Hegde3,4
1Division of Hematology & Medical Oncology, Department of Medicine, University of Missouri, Columbia, MO, USA.
World Journal of Oncology
|March 28, 2024
Summary
Pigs are valuable biomedical models for human diseases due to genetic and physiological similarities. This review highlights their use in preclinical cancer research, showcasing their strengths and potential.
Area of Science:
- Biomedical Research
- Comparative Medicine
- Oncology
Background:
- Pigs are increasingly utilized as translational biomedical models for human pathophysiology.
- Genome annotation has significantly advanced the translatability of pigs in biomedical research.
- Similarities in anatomy, physiology, genetics, and immunology make pigs suitable preclinical models for human diseases.
Purpose of the Study:
- To review current research utilizing pigs as preclinical models for cancer.
- To highlight the strengths and opportunities of using pigs in studying human cancers.
Main Methods:
- Literature review of studies employing pigs in cancer research.
- Analysis of anatomical, physiological, genetic, and immunological parallels between pigs and humans relevant to cancer.
Main Results:
- Pigs have been instrumental in understanding human pathophysiology across various domains, including craniofacial, ophthalmology, reproduction, wound healing, musculoskeletal, and cancer.
- The review identifies specific strengths and opportunities for pigs as models in diverse human cancer research.
Conclusions:
- Pigs offer a comprehensive preclinical platform for advancing human cancer research.
- Further exploration of pig models is crucial for gaining deeper insights into human cancer pathophysiology and developing novel therapies.
