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Updated: Jun 29, 2025

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy

Published on: October 25, 2024

Intrauterine insemination: prognostic factors.

Carla Maria Franco Dias¹, Gabriel Borges Tavares Vitorino¹, Suelen Maria Parizotto Furlan¹

¹Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil.

JBRA Assisted Reproduction

|March 28, 2024

Summary

The combination of gonadotropins and letrozole for ovulation induction and achieving over 5 million/mL of progressive sperm significantly increases live birth rates in intrauterine insemination (IUI) cycles. Other factors did not show a correlation.

Keywords:

clinical pregnancy rate infertility intrauterine insemination live birth rate prognostic factors

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Human Egg Maturity Assessment and Its Clinical Application

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Published on: August 19, 2019

Area of Science:

Reproductive Medicine
Obstetrics and Gynecology
Infertility Research

Background:

Intrauterine insemination (IUI) is a common first-line treatment for infertility.
Identifying prognostic factors is crucial for optimizing IUI success rates.
Previous studies have yielded conflicting results regarding predictive variables in IUI.

Purpose of the Study:

To investigate maternal and paternal prognostic factors influencing IUI outcomes.
To assess the impact of different ovarian stimulation protocols on IUI success.
To determine key predictors for clinical pregnancy and live birth in IUI cycles.

Main Methods:

Retrospective observational study of 341 IUI cycles (2016-2020).
Analysis of maternal age, paternal age, BMI, infertility causes, ovarian response, and semen parameters.
Statistical analysis including Wilcoxon's test, chi-square test, and logistic regression.

Main Results:

Ovulation induction with gonadotropins plus letrozole significantly increased live birth rates (OR 4.3286).
Post-capacitation progressive sperm count ≥ 5 million/mL was also correlated with live birth.
Maternal/paternal age, obesity, multifollicular growth, and endometrial thickness were not significant predictors.

Conclusions:

The protocol using gonadotropins plus letrozole is a significant factor for IUI success.
Adequate progressive sperm count is essential for achieving live births after IUI.
These findings help refine patient selection and treatment protocols for IUI.