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Co-prevalence of arterial aneurysm location - a correlation analysis based on a retrospective cross-sectional
Daniel Körfer1, Samuel Kilian2, Caspar Grond-Ginsbach1
1Department of Vascular and Endovascular Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Insights
Arterial aneurysm locations are not random. Paired artery aneurysms, like iliac or carotid, frequently co-occur. This finding impacts screening strategies for arterial aneurysms.
Area of Science:
- Vascular Surgery
- Medical Imaging
- Epidemiology
Background:
- Arterial aneurysms represent a significant vascular pathology.
- Understanding the co-prevalence of aneurysm locations is crucial for risk stratification.
- Previous studies have not systematically investigated the co-occurrence patterns of arterial aneurysms.
Purpose of the Study:
- To systematically investigate the co-prevalence of arterial aneurysm locations.
- To identify specific patterns and correlations in the occurrence of multiple aneurysms within patients.
- To inform clinical practice and screening program development for arterial aneurysms.
Main Methods:
- Retrospective, single-centre, cross-sectional observational study.
- Inclusion of patients diagnosed with arterial aneurysms between 2006 and 2016.
- Exclusion of patients with hereditary connective tissue disorders, inflammatory diseases, or non-true aneurysms.
- Statistical analysis using correlation coefficients and Fisher's exact test to assess co-prevalence.
Main Results:
- Analysis of 951 patients with at least two aneurysms revealed non-random co-prevalence.
- Highest correlations observed in bilateral combinations of iliac, femoral, and popliteal arteries.
- Lowest correlations found between abdominal aortic aneurysms and visceral, popliteal, or ascending aorta aneurysms.
Conclusions:
- Aneurysm co-prevalence is significantly non-random, indicating specific location associations.
- Findings suggest that the presence of an aneurysm in one location increases the likelihood of aneurysms in specific other locations.
- These insights are vital for optimizing screening protocols and patient management strategies for arterial aneurysms.
Abstract:
Background: The aim of this retrospective single-centre cross-sectional observational study was to investigate co-prevalence of arterial aneurysm location systematically. Patients and methods: Patients with the diagnosis of any arterial aneurysm from January 2006 to January 2016 were investigated in a single centre. Patients with hereditary disorders of connective tissue, systemic inflammatory disease, or arterial pathologies other than true aneurysms were excluded. Aneurysm locations were assessed for every patient included. For patients with at least two co-existing aneurysms, co-prevalence of aneurysm location was investigated by calculating correlation coefficients and applying Fisher's exact test. This study report is prepared according to the STROBE statement. Results: Of 3107 identified patients with arterial aneurysms, 918 were excluded. Of the remaining 2189 patients, 951 patients with at least two aneurysms were included in the study. Bilateral aneurysm combinations of paired iliac, femoral and popliteal arteries showed the highest correlation (ϕ=0.35 to 0.67), followed by bilateral combinations of subclavian (ϕ=0.36) and internal carotid (ϕ=0.38) arteries. Abdominal aortic aneurysms in combination with visceral artery aneurysms (ϕ=-0.24 to -0.12), popliteal arteries (ϕ=-0.22) and the ascending aorta (ϕ=-0.19) showed the lowest correlation, followed by the descending aorta in combination with the common iliac arteries (ϕ=-0.12 to -0.13). Conclusions: In our study sample, aneurysm co-prevalence was highly non-random. This should be considered in the context of aneurysm screening programs.
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