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Published on: June 28, 2014
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Metabolite transport across central nervous system barriers
Gesa Carstens1, Marcel M Verbeek2, Ursula K Rohlwink3
1Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands.
Summary
Cerebrospinal fluid (CSF) metabolomics aids neurological disease understanding. This review details metabolite transport across barriers, crucial for interpreting CSF metabolite levels and improving diagnostics.
Area of Science:
- Neuroscience
- Biochemistry
- Physiology
Background:
- Cerebrospinal fluid (CSF) metabolomics is vital for diagnosing and understanding neurological diseases.
- Metabolite levels in CSF reflect both brain metabolism and transport across barriers.
- Key barriers include the blood-brain, blood-CSF, and blood-spinal cord barriers.
Purpose of the Study:
- To summarize current knowledge on transporters involved in metabolite exchange between blood and CSF.
- To provide a reference for future CSF metabolomic studies.
- To elucidate the routing of metabolites from blood to CSF and vice versa.
Main Methods:
- Literature review of transport mechanisms across CNS barriers.
- Analysis of aquaporins and membrane-bound carrier proteins.
- Synthesis of data on metabolite influx and efflux.
Main Results:
- Detailed information on the location and function of transporters regulating metabolite passage.
- Understanding of passive and active transport processes at the barriers.
- A comprehensive overview of metabolite transport pathways.
Conclusions:
- Transport processes significantly influence CSF metabolite concentrations.
- Considering transporter function is essential for accurate CSF metabolomic interpretation.
- This knowledge is critical for advancing neurological disease diagnostics and research.
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