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Adoption of Decentralization: Are Our Perceptions Holding Us Back?
Lindsay Kehoe1, Sara Bristol Calvert1, Zachary Hallinan1
1Clinical Trials Transformation Initiative, Duke Clinical Research Institute, 300 West Morgan Street, Suite 800, Durham, NC, 27701, United States.
None:
Incorporating decentralized approaches into clinical trials is a critical innovation with potential implications for improved accessibility and diversity, as well as lower burden for participants and caregivers. As we move forward in a collective effort to modernize clinical trials, we consistently hear of hurdles that interfere with the adoption of decentralized approaches. But are these hurdles really the impediments we think they are? In this commentary, we offer three perceptions that are commonly heard as impediments to the adoption of digital and decentralized clinical trials. Leveraging the Clinical Trial Transformation Initiative's Digital Health Trial hub of work, interactions with members and regulators, and observations related to adoption, we address those perceptions and note some resources that exist to overcome them. In working through these barriers, we can instill confidence in sponsors and designers to leverage all the clinical trial design tools available to them to advance the use of decentralized approaches.
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