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Prognosis of primary breast salivary gland-type carcinoma: a propensity score-matching analysis with invasive
1Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia. eschng@usm.my.
Breast Cancer (Tokyo, Japan)
|March 28, 2024
Summary
Primary breast salivary gland-type carcinoma (SGTCA) has similar outcomes to invasive carcinoma of no special type (NST) when adjusted for prognostic factors. Tumor grade and AJCC stage are crucial for managing SGTCA.
Area of Science:
- Oncology
- Pathology
- Cancer Research
Background:
- Primary breast salivary gland-type carcinoma (SGTCA) is rare, with limited data on its clinical features and prognosis.
- Management guidelines for SGTCA lack robust evidence.
- Comparison with common invasive breast carcinoma of no special type (NST) is needed.
Purpose of the Study:
- To assess clinicopathological features and prognosis of primary breast SGTCA.
- To compare the prognosis of SGTCA with invasive breast carcinoma NST.
- To identify significant prognostic factors for SGTCA.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database.
- Extracted data on primary breast SGTCA cases diagnosed over the past decade.
- Employed propensity score-matching to compare SGTCA prognosis with invasive carcinoma NST.
Main Results:
- Included 488 SGTCA cases and 375,660 invasive carcinoma NST cases (ratio 1:770).
- Adenoid cystic carcinoma (81%) and secretory carcinoma (13%) were the main SGTCA subtypes.
- Tumor grade 3, higher AJCC stage, acinic cell carcinoma type, and HER2 overexpression were associated with worse survival in univariate analysis. After adjustment, tumor grade and AJCC stage remained significant. SGTCA survival advantage diminished post-adjustment.
Conclusions:
- Management of SGTCA should emphasize tumor grade, AJCC stage, acinic cell carcinoma type, and HER2 overexpression.
- Conventional prognostic factors are important for SGTCA.
- SGTCA prognosis is similar to invasive carcinoma NST after adjusting for confounding variables.
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