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In vitro activity of selected antimicrobials against methicillin-resistant Staphylococcus pseudintermedius of canine

Magdalena Kizerwetter-Świda1, Dorota Chrobak-Chmiel1, Ilona Stefańska1

  • 1Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.

Veterinary Medicine and Science
|March 28, 2024
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) in dogs shows high resistance to common antibiotics. Amikacin and vancomycin remain effective, offering potential treatment options for MRSP infections.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Companion Animal Health

Background:

  • Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a significant veterinary pathogen.
  • Limited antimicrobial options are typically effective against MRSP isolates.
  • Canine MRSP infections pose a growing clinical challenge.

Purpose of the Study:

  • To evaluate the in vitro activity of selected antimicrobials against clinical MRSP isolates from dogs.
  • To assess the efficacy of last-choice drugs against canine MRSP.
  • To identify potential therapeutic agents for MRSP infections in companion animals.

Main Methods:

  • Antimicrobial susceptibility testing (AST) was performed on 41 clinical MRSP isolates.
  • Disk diffusion and minimal inhibitory concentration (MIC) methods were utilized.
  • Guidelines for staphylococci of canine or human origin were applied for interpretation.

Main Results:

  • High prevalence of resistance was observed for enrofloxacin (97.6%) and clindamycin (97.6%).
  • Resistance to doxycycline (83.0%) and gentamicin (68.3%) was also common.
  • All isolates remained susceptible to amikacin, vancomycin, mupirocin, and linezolid.

Conclusions:

  • Amikacin and vancomycin are potential treatment options for MRSP infections in dogs.
  • Extended susceptibility testing for agents like amikacin and chloramphenicol is recommended.
  • Establishing clinical breakpoints for veterinary-specific antimicrobials is crucial for diagnostics.
Keywords:
Polandantimicrobial resistancedisk diffusionmethicillin‐resistant Staphylococcus pseudintermediusminimal inhibitory concentration

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