Humanized mice for studying HIV latency and potentially its eradication

Area of Science:

• Immunology
• Virology
• Infectious Diseases

Background:

• HIV latency presents a major obstacle to a cure, with the virus persisting in latent reservoirs within CD4+ T cells and macrophages.
• Understanding HIV pathogenesis and the establishment of these latent reservoirs is critical for developing effective eradication strategies.

Approach:

• This review examines the role of humanized mouse models in studying HIV latency and evaluating potential cure strategies.
• It highlights research into molecular mechanisms and pathogenesis of HIV latency in these models.
• The importance of analytical cART interruption in humanized mouse studies is emphasized for assessing latent reservoir impact.

Key Points:

• Humanized mouse models offer vital insights into the dynamics of HIV infection and latency.
• These models are instrumental in testing novel strategies aimed at eradicating the latent HIV reservoir.
• Progress in understanding and targeting HIV latency is ongoing, with humanized mice playing a central role.

Conclusions:

• Humanized mouse models are indispensable tools in HIV research, significantly contributing to the pursuit of a functional or sterile cure for HIV.
• Continued research using these models is essential for overcoming the challenges associated with eliminating latent HIV reservoirs.