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Updated: Jun 29, 2025
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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
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Phthalate exposure aggravates periodontitis by activating NFκB pathway.
Wei Wu1, Wenxiu Jiang2, Yongmiao Zhou1
1Department of Dental Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China.
Ecotoxicology and Environmental Safety
|March 28, 2024
Summary
Exposure to multiple phthalates is linked to periodontitis in US adults. Di(2-ethylhexyl) phthalate (DEHP) exposure aggravates periodontitis by increasing inflammation via the NFκB pathway.
Area of Science:
- Environmental Health
- Periodontology
- Toxicology
Background:
- Phthalates are common plasticizers linked to various human diseases.
- The association between phthalate exposure and periodontitis remains unexplored.
- This study investigates the relationship between phthalates and periodontitis, including underlying mechanisms.
Purpose of the Study:
- To determine the association between phthalate metabolites and periodontitis in US adults.
- To explore the dose-response relationship between phthalate exposure and periodontitis.
- To elucidate the role and mechanism of Di(2-ethylhexyl) phthalate (DEHP) in periodontitis development.
Main Methods:
- Logistic regression models analyzed the association between phthalate metabolites and periodontitis.
- Generalized additive and piecewise logistic models assessed dose-response relationships.
- Cell and animal models, including mice with periodontitis, were used to investigate DEHP's mechanism, employing transcriptome sequencing, bioinformatics, western blot, and immunofluorescence.
Main Results:
- Several phthalate metabolites, including MEHP, MCPP, MEHHP, MEOHP, MiBP, and MECPP, were identified as independent risk factors for periodontitis.
- MEHHP, a DEHP metabolite, demonstrated the most significant impact on periodontitis.
- Increased inflammation and activation of the NFκB pathway were observed in periodontitis models exposed to DEHP.
Conclusions:
- Phthalate exposure is positively associated with periodontitis in US adults aged 30-80.
- DEHP exacerbates periodontitis by activating the NFκB pathway and increasing inflammation.
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