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Methods for Including Adverse Events in Economic Evaluations: Suggestions for Improvement
Salah Ghabri1, Dalia Dawoud2, Michael Drummond3
1Department of Medical Evaluation, French National Authority for Health (HAS), Saint-Denis La Plaine, France.
Summary
Incorporating adverse events (AEs) into health technology economic evaluations is crucial for informed healthcare decisions. This study identifies key issues and proposes recommendations for best practices in handling AEs within economic models.
Area of Science:
- Health Economics
- Pharmacoeconomics
- Health Technology Assessment
Background:
- Effective healthcare decisions require integrating safety outcomes, specifically adverse events (AEs), into economic evaluations of health technologies.
- Current economic evaluations often face challenges in adequately incorporating the impact of AEs on costs and quality of life.
Purpose of the Study:
- To identify critical issues in incorporating adverse events (AEs) into health technology economic evaluations.
- To explore perspectives and develop recommendations for best practices in handling AEs in these evaluations.
Main Methods:
- Focused on methodological challenges in integrating AEs into economic evaluations.
- Examined AE incorporation in decision models, AE terminology, estimation of AE consequences (quality of life and costs), and uncertainty analysis.
Main Results:
- Highlighted issues in decision model integration, AE terminology, and quantifying AE impacts on quality of life and costs.
- Demonstrated the need for better real-world safety data and improved methods for capturing AE consequences.
Conclusions:
- Key methodological issues in incorporating adverse drug events into economic evaluations were identified.
- Recommendations were proposed to guide health technology assessment agencies and researchers in developing robust research practices.
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