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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Related Experiment Video

Updated: Jun 29, 2025

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

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[Cell therapy and wound repair].

Y Liu1, X Y Liu1

  • 1Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
|March 28, 2024
PubMed
Summary

Cell therapy, using living cells or their derivatives, shows promise for treating difficult wounds. Ongoing research aims to optimize these therapies for better clinical outcomes in wound repair.

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Tissue Engineering

Background:

  • Cell therapy, encompassing living cell-based and cell-derivative therapies (extracellular vesicles, bioactive molecules), is a significant research area.
  • Refractory wound repair presents a major clinical challenge, driving the need for innovative therapeutic strategies.
  • Advancements in material science and cell biology are pivotal for developing next-generation cell therapies.

Approach:

  • This review synthesizes current knowledge on cell types utilized in wound treatment.
  • It summarizes novel cell therapy technologies and their applications in wound repair.
  • The review identifies challenges in the clinical translation of existing cell therapies.

Key Points:

  • Explores diverse cell types for wound healing applications.

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  • Highlights emerging cell therapy technologies and their potential.
  • Addresses limitations and hurdles in current clinical cell therapy for wounds.

    • Conclusions:

    • Cell therapy offers a promising avenue for refractory wound repair.
    • Further optimization and innovation in cell therapy systems are crucial.
    • Improved cell therapy approaches are expected to enhance clinical wound treatment efficacy.