Frequency and implications of malnutrition in systemic sclerosis
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View abstract on PubMed
Summary
This summary is machine-generated.Malnutrition is prevalent in systemic sclerosis (SSc), affecting 43% of patients. This condition significantly worsens survival, quality of life, and physical function in individuals with SSc.
Area Of Science
- Rheumatology
- Clinical Nutrition
- Scleroderma Research
Background
- Systemic sclerosis (SSc) is a complex autoimmune disease.
- Malnutrition is a recognized complication in chronic diseases.
- The Global Leadership Initiative on Malnutrition (GLIM) criteria provide a standardized diagnostic framework.
Purpose Of The Study
- To determine the prevalence of malnutrition in SSc using GLIM criteria.
- To assess the impact of malnutrition on survival, quality of life, and physical function in SSc patients.
Main Methods
- Analysis of data from the Australian Scleroderma Cohort Study.
- Inclusion of SSc patients meeting ACR/EULAR criteria with weight and height measurements.
- Application of GLIM criteria (weight loss, BMI, muscle atrophy) for malnutrition diagnosis.
- Statistical analyses including logistic regression and survival models (Kaplan-Meier, Cox proportional hazards).
Main Results
- 43% of 1903 SSc participants were diagnosed with malnutrition, 33% severely.
- Malnourished patients were older, more likely to have diffuse cutaneous SSc, and higher disease severity.
- Gastrointestinal involvement, multimorbidity, pulmonary arterial hypertension, and upper GI symptoms were associated with malnutrition.
- Poorer health-related quality of life and physical function were observed in malnourished individuals.
- Malnutrition was independently associated with worse survival (HR 1.4).
Conclusions
- Malnutrition is a frequent and significant issue in systemic sclerosis.
- GLIM criteria effectively identify malnutrition in SSc.
- Malnutrition is linked to adverse outcomes, including reduced survival and impaired physical function and quality of life.
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