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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jun 29, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Stage-Based Detection Methods and Recurrence Patterns for Cutaneous Melanoma.

F Grace Sullivan¹, Keith B Adler¹, Madeleine D Boudreaux¹

¹Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA.

The American Surgeon

|March 29, 2024

Summary

This summary is machine-generated.

Melanoma recurrence varies by stage. Patient-reported symptoms and imaging effectively detect recurrences, with imaging crucial for advanced stages. Early detection aids melanoma surveillance.

Keywords:

melanoma surgical oncology

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Last Updated: Jun 29, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

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Published on: May 5, 2011

Area of Science:

Oncology
Dermatology
Medical Imaging

Background:

Melanoma surveillance guidelines lack standardization.
Understanding melanoma recurrence patterns is crucial for effective patient management.
Current detection methods include patient complaint (PC), physical exam (PE), cross-sectional imaging (CSI), and ultrasound (US).

Purpose of the Study:

To analyze melanoma recurrence patterns across different stages.
To evaluate the effectiveness of various detection methods for melanoma recurrence.
To inform optimal melanoma surveillance strategies.

Main Methods:

Retrospective review of 276 resected melanoma patients (Stage I, II, III).
Analysis of recurrence detection using PC, PE, CSI, and US.
Correlation of recurrence rates and detection methods with disease stage.

Main Results:

Recurrence rates were 8% (Stage I), 24% (Stage II), and 27% (Stage III).
Patient complaint was the primary detection method for Stage I (55%), while CSI was key for Stages II (45%) and III (59%).
Recurrence patterns shifted from local (Stage I) to regional and distant (Stages II and III).

Conclusions:

History and physical (H&P) are essential for all melanoma patients.
Cross-sectional imaging is a vital surveillance tool, particularly for higher-stage melanoma.
Tailored surveillance strategies based on stage are recommended for optimal melanoma recurrence detection.