[Genetic factors in degenerative disc disease]

Area of Science:

• Biomedical research
• Genetics
• Spine pathology

Background:

• Degenerative disc disease (DDD) is a significant cause of back pain.
• The pathogenesis of DDD involves complex biological processes.
• Understanding genetic contributions to DDD is crucial for developing targeted therapies.

Approach:

• Comprehensive literature review of studies from 2002-2022.
• Inclusion of 43 significant studies after rigorous exclusion criteria.
• Keywords: degenerative spine lesions, intervertebral disc herniation, pathogenesis, genetic regulation.

Key Points:

• Literature confirms the involvement of proinflammatory cytokines, growth factors, and osteodestructive processes in DDD.
• Existing data on the genetic regulation of these processes is fragmented.
• Specific factors like microRNA, TGF-b, VEGF, and MMP require further investigation.

Conclusions:

• The genetic basis of degenerative disc disease remains incompletely elucidated.
• Further research into genetic regulation is essential for advancing DDD understanding.
• Identifying the precise roles of specific genetic factors will guide future therapeutic strategies.