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Updated: Jun 29, 2025

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
Valvular fibroelastomas complicated by Coxiella burnetti endocarditis
Eyal Meltzer1,2, Tawfiq Abu Al-Rub1, Rafael Kuperstein3
1Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
Abstract:
Cardiac papillary fibroelastoma (CPF) is a valvular tumor that may be mistaken for infective endocarditis (IE). We describe a case of CPF complicated by Coxiella burnetti IE. According to Duke's criteria, a diagnosis of IE was repeatedly considered as excluded or established during the clinical course, highlighting the criteria limitations.
Insights
Cardiac papillary fibroelastoma, a heart valve tumor, can mimic infective endocarditis (IE). A case complicated by Coxiella burnetti IE demonstrates diagnostic challenges and limitations of current criteria.
Area of Science:
- Cardiology
- Cardiac Surgery
- Infectious Diseases
Background:
- Cardiac papillary fibroelastoma (CPF) is a rare, benign cardiac tumor.
- CPFs can present with embolic events or symptoms mimicking other cardiac conditions.
- Infective endocarditis (IE) is a serious infection that can be difficult to diagnose.
Purpose of the Study:
- To report a case of cardiac papillary fibroelastoma complicated by Coxiella burnetti infective endocarditis.
- To highlight the diagnostic challenges and limitations of Duke's criteria in such cases.
Main Methods:
- Case report detailing clinical presentation, diagnostic workup, and management.
- Review of relevant literature on CPF and IE.
Main Results:
- The patient presented with symptoms suggestive of IE, complicating the diagnosis of CPF.
- Duke's criteria were inconsistently applied, leading to diagnostic uncertainty.
- The final diagnosis required a combination of clinical, microbiological, and imaging findings.
Conclusions:
- CPF can mimic IE, posing significant diagnostic challenges.
- Current diagnostic criteria for IE may be insufficient in cases involving underlying cardiac tumors.
- Multidisciplinary evaluation is crucial for accurate diagnosis and management.
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