Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

478
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
478
Necrosis01:16

Necrosis

4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
Folliculogenesis01:20

Folliculogenesis

744
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
744
Ovarian Cycle01:27

Ovarian Cycle

1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

354
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
354

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A predictive model for immunotherapy in extensive-stage small cell lung cancer based on peripheral blood.

Journal of thoracic disease·2026
Same author

Association of Pre-Transplant Tyrosine Kinase Inhibitor Therapy With Tumor Response and Survival in Hepatocellular Carcinoma: A 10-Year Retrospective Cohort Study of 427 Patients.

World journal of surgery·2026
Same author

A barrier to human embryogenesis involves dysregulated 3D genome reprogramming and ZGA collapse.

Communications biology·2026
Same author

Neohesperidin Regulates Lipid Metabolism and Ameliorates MASLD by Targeting ECHS1.

Phytotherapy research : PTR·2026
Same author

The impact of regressed endometrial hyperplasia on reproductive outcomes following frozen embryo transfer: a propensity score-matched cohort study.

Frontiers in endocrinology·2026
Same author

Robust Heterojunction Nanoconstructs Enable Precise Decipherment of Aqueous Humor Metabolic Profiles in Multiple Retinal Diseases.

Analytical chemistry·2026

Related Experiment Video

Updated: Jun 29, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.2K

Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS.

Xinyu Li1,2, Yunying Lin1,2, Xiaoyue Cheng1,2

  • 1Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Human Reproduction Open
|March 29, 2024
PubMed
Summary

Polycystic ovary syndrome (PCOS) is linked to increased ovarian ferroptosis, a type of cell death. Inhibiting ferroptosis improved PCOS symptoms in a rat model, suggesting it as a potential therapeutic target.

Keywords:
PCOSandrogenferroptosisnuclear receptor coactivator 4ovarian dysfunction

More Related Videos

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.0K
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

959

Related Experiment Videos

Last Updated: Jun 29, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.2K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.0K
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

959

Area of Science:

  • Reproductive Biology
  • Cell Death Mechanisms
  • Endocrinology

Background:

  • Programmed cell death is crucial for ovarian follicle development, but specific mechanisms in PCOS remain unclear.
  • Ferroptosis, an iron-dependent cell death, is implicated due to observed iron metabolism issues in PCOS.
  • Previous research suggests noncoding RNAs may promote ferroptosis in ovarian cells, but direct evidence in PCOS is limited.

Purpose of the Study:

  • To investigate if ovarian ferroptosis plays an active role in the development of polycystic ovary syndrome (PCOS).
  • To explore the therapeutic potential of inhibiting ferroptosis in PCOS.

Main Methods:

  • Evaluated ovarian ferroptosis markers (iron, MDA, proteins) in human granulosa cells (hGCs) and PCOS rat ovaries.
  • Utilized dihydrotestosterone (DHT) to induce PCOS-like conditions in vitro and dehydroepiandrosterone (DHEA) to create a PCOS rat model.
  • Administered ferrostatin-1 (Fer-1) to inhibit ferroptosis and RSL3 to induce it in rats, assessing various PCOS indicators.

Main Results:

  • PCOS ovaries and hGCs showed increased ferroptosis markers, including higher Fe2+ and MDA levels.
  • DHT treatment induced ferroptosis via NOCA4-dependent ferritinophagy.
  • Ferrostatin-1 treatment in PCOS rats ameliorated key symptoms like hyperandrogenism, anovulation, and polycystic ovary morphology.

Conclusions:

  • Androgen-induced ovarian ferroptosis is implicated in PCOS pathogenesis.
  • Inhibiting ferroptosis shows promise as a targeted treatment strategy for PCOS.
  • Further research is needed to elucidate the ferroptosis-hyperandrogenism cycle and its presence across PCOS heterogeneity.