Genetic heterogeneity in cardiovascular disease across ancestries: Insights for mechanisms and therapeutic...

Area of Science:

• Genetics and Precision Medicine
• Cardiovascular Research

Background:

• Cardiovascular diseases (CVDs) stem from complex interactions between genetics, lifestyle, and environment.
• Genetic heterogeneity significantly impacts CVD molecular mechanisms, clinical presentation, and disease progression.
• Current therapeutic development often overlooks genetic diversity within populations.

Purpose of the Study:

• To review the molecular and clinical heterogeneity of CVDs across diverse population ancestry groups.
• To explore how genetic heterogeneity informs therapeutic interventions and personalized medicine for CVDs.
• To highlight the utility of polygenic risk scores and Mendelian randomization in understanding CVD mechanisms.

Main Methods:

• Literature review focusing on genetic heterogeneity in cardiovascular diseases.
• Analysis of studies examining CVD mechanisms across diverse ancestral populations.
• Discussion of advanced genetic tools like polygenic risk scores and Mendelian randomization.

Main Results:

• CVD mechanisms and progression vary significantly due to genetic differences across ancestral groups.
• Genetic heterogeneity provides opportunities for tailored therapeutic strategies and personalized medicine.
• Polygenic risk scores and Mendelian randomization offer robust insights into CVD etiology and treatment.

Conclusions:

• Leveraging genetic variability across diverse populations is crucial for advancing precision medicine in cardiovascular health.
• A deeper understanding of population-specific genetic factors will improve CVD onset prediction, progression monitoring, and treatment response.
• Personalized therapeutic interventions informed by genetic diversity promise to enhance CVD management outcomes.