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Updated: Jun 29, 2025
08:21
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
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Cardiovascular precision medicine - A pharmacogenomic perspective
Sandosh Padmanabhan1, Clea du Toit1, Anna F Dominiczak1
1BHF Glasgow Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Cambridge Prisms. Precision Medicine
|March 29, 2024
Summary
Precision medicine uses individual patient data for tailored treatments. Pharmacogenomics (PGx) is key for personalized cardiovascular care, but its clinical use is still developing.
Area of Science:
- Pharmacogenomics
- Cardiovascular Diseases
- Precision Medicine
Background:
- Current one-size-fits-all treatments are effective for only half of patients.
- Precision medicine integrates clinical and biological data for personalized diagnosis and treatment.
- Pharmacogenomics (PGx) is a crucial component of precision medicine.
Purpose of the Study:
- To review the current status of pharmacogenomics in cardiovascular diseases.
- To identify key enablers and barriers for implementing cardiovascular PGx in clinical practice.
Main Methods:
- Literature review of pharmacogenomics in cardiovascular diseases.
- Analysis of existing pharmacogenomic implementation examples.
- Identification of factors facilitating or hindering clinical adoption.
Main Results:
- Nearly all individuals carry actionable pharmacogenetic variants.
- A significant portion of adults over 50 are on medications with known PGx associations.
- The application of PGx in cardiovascular medicine is still evolving.
Conclusions:
- Pharmacogenomics holds significant potential for personalized cardiovascular medicine.
- Addressing implementation barriers is essential for widespread clinical adoption.
- Further research and development are needed to fully realize the benefits of cardiovascular PGx.
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