Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Lobular carcinoma, a common hormone receptor-positive breast cancer, is increasing in postmenopausal women. Ovarian hormone exposure, from therapies and reproductive factors, is linked to its development and progression.
Area Of Science
- Oncology
- Endocrinology
- Epidemiology
Background
- Lobular carcinoma is the most common special histological subtype of breast cancer, predominantly hormone receptor-positive.
- Invasive lobular carcinoma rates are rising globally in postmenopausal women, unlike other hormone receptor-positive breast cancers.
- This trend is associated with exogenous ovarian hormone exposure, such as hormone replacement therapy.
Approach
- This review summarizes epidemiological data on ovarian hormones and lobular breast cancer.
- It highlights mechanistic links between ovarian hormones and lobular breast cancer etiology and biology.
- The review focuses on understanding the role of ovarian hormones in lobular breast cancer genesis and progression.
Key Points
- Increased lifetime exposure to endogenous ovarian hormones through reproductive factors is linked to higher lobular breast cancer risk.
- Exogenous ovarian hormone exposure, including hormone replacement therapy, is also associated with increased lobular carcinoma rates.
- Ovarian hormones play a significant role in the development and progression of lobular breast cancer.
Conclusions
- Ovarian hormones are implicated in the etiology and biology of lobular breast cancer.
- Further research into hormonal influences can inform prevention and treatment strategies for lobular breast cancer.
- Understanding these associations is crucial for addressing the rising incidence of lobular carcinoma.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...