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Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and

Stephen B Beres1, Randall J Olsen1,2, S Wesley Long1,2

  • 1Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, United States.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|March 29, 2024
PubMed

Insights

A new variant of Group A Streptococcus (M1UK clade) has caused serious infections. Genomic analysis reveals a likely origin in Scotland, preceding outbreaks in Iceland.

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Group A Streptococcus (GAS) M1UK clade infections are an emerging public health concern.
  • Recent serious human infections caused by this clade have been reported in Europe.

Purpose of the Study:

  • To investigate the genomic relationship between M1UK isolates from different geographical locations.
  • To identify the potential origin and transmission dynamics of the M1UK variant.

Main Methods:

  • Whole-genome sequencing of Group A Streptococcus M1 isolates.
  • Phylogenetic analysis to determine evolutionary relationships.

Main Results:

  • A close genomic relationship was identified between M1UK isolates from Scotland and Iceland.
  • Phylogenetic analysis suggests a Scottish isolate or related strain was the precursor to the Icelandic M1UK variant.

Conclusions:

  • The M1UK variant responsible for recent Icelandic infections likely originated from Scotland.
  • Understanding the genomic epidemiology of GAS is crucial for tracking and controlling outbreaks.
Keywords:
Infectious DiseaseMolecular EpidemiologyPhylogeneticsPopulation GenomicsStreptococcus

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