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Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology
Hanako Yoshimura1, Yoshito Takeda1, Yuya Shirai1
1Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
The Journal of Allergy and Clinical Immunology
|March 29, 2024
Summary
Novel biomarkers from serum extracellular vesicles (EVs) can identify specific asthma types. Galectin-10 (Gal10) in EVs shows promise for diagnosing airway obstruction and reflects disease pathology.
Area of Science:
- Biochemistry
- Immunology
- Pulmonology
Background:
- Asthma biomarkers are crucial for understanding diverse disease phenotypes.
- Current biomarkers lack specificity for different asthma endotypes.
Purpose of the Study:
- To discover novel biomarkers from serum extracellular vesicles (EVs).
- To identify biomarkers reflecting tissue pathology in bronchial asthma (BA).
Main Methods:
- Proteomic analysis of serum EVs using data-independent acquisition.
- Validation of identified biomarkers in cohorts of asthma patients and controls.
- Correlation analysis of EV biomarkers with tissue pathology in chronic rhinosinusitis.
Main Results:
- Identified 3032 proteins in serum EVs, with 23 differentially expressed in eosinophilic asthma (EA).
- Discovered 5 EA-specific biomarkers, including galectin-10 (Gal10).
- Gal10 in EVs demonstrated superior diagnostic capability for airway obstruction compared to eosinophils.
Conclusions:
- Serum EV-derived biomarkers, particularly Gal10, reflect BA pathophysiology.
- These biomarkers offer potential for novel liquid biopsy approaches in asthma diagnosis and management.
Keywords:
Biomarkerbioinformaticsbronchial asthmachronic rhinosinusitisexosomeliquid biopsynasal polyppersonalized medicineproteomicstype 2 inflammationMore Related Videos
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