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Related Experiment Video

Updated: Jun 29, 2025

In Vivo Thoracic Dorsal Root Ganglia (DRG) Calcium Imaging and ECG Recording for Studying Peripheral Nerve Stimulation
06:34

In Vivo Thoracic Dorsal Root Ganglia (DRG) Calcium Imaging and ECG Recording for Studying Peripheral Nerve Stimulation

Published on: August 16, 2024

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Dorsal Root Ganglion Stimulation Relieves Chronic Neuropathic Pain Along With a Decrease in Cortical γ Power.

Matthias Hubert Morgalla1, Yi Zhang1, Bankim Subhash Chander2

  • 1Department of Neurosurgery, Eberhard-Karls University, Tübingen, Germany.

Neuromodulation : Journal of the International Neuromodulation Society
|March 29, 2024
PubMed
Summary
This summary is machine-generated.

Dorsal root ganglion stimulation (DRGS) effectively reduces chronic neuropathic pain. This therapy is linked to decreased gamma-band power in the brain, suggesting reduced nerve hyperexcitability and offering a potential biomarker for treatment efficacy.

Keywords:
Chronic neuropathic paindorsal root ganglion stimulationgroin painknee painγ-band power

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Area of Science:

  • Neuromodulation
  • Pain Management
  • Neuroscience

Background:

  • Dorsal root ganglion stimulation (DRGS) is a key neuromodulative intervention for localized chronic pain.
  • Gamma-band (γ-band) oscillations correlate with chronic pain intensity in affected patients.

Purpose of the Study:

  • To investigate the role of cortical gamma-band power in chronic neuropathic pain relief following DRG stimulation (DRGS).

Main Methods:

  • Nine patients with chronic neuropathic pain undergoing DRGS therapy were studied.
  • Electroencephalography (EEG) was used to measure broadband gamma (γ) power, alongside the numeric rating scale (NRS) for pain assessment.
  • EEG and NRS data were collected on day 1 and day 7 post-DRGS implantation for comparison.

Main Results:

  • Numeric rating scale (NRS) scores significantly decreased from day 1 to day 7 post-DRGS (p = 0.007).
  • Resting-state gamma (γ) power (30-45 Hz) significantly decreased contralaterally to the painful limb (p = 0.021).
  • A positive correlation was observed between gamma (γ) band power and NRS ratings (rs = 0.628, p = 0.005).

Conclusions:

  • A lateralized decrease in broadband gamma (γ) power supports reduced nociceptive system hyperexcitability with DRGS therapy.
  • Gamma (γ) band power may serve as a biomarker for assessing DRGS efficacy during the pre-implantation test phase.