Related Experiment Video
Updated: Jun 29, 2025
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures
Thomas W Robinson1, Corinne E Gautreaux1, Yann-Leei L Lee1
1Division of Trauma, Acute Care Surgery, and Burns, Department of Surgery, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, AL, USA.
Abstract:
Gustilo type III open fractures involve extensive soft tissue damage and wound contamination that pose significant infection risks. The historical standard for antibiotic prophylaxis has been cefazolin and gentamicin. We conducted a retrospective cohort study of lower extremity type III open fractures treated with ceftriaxone alone for prophylaxis. Eighty-six patients were identified. Nearly all (98%) were managed with appropriate antibiotics, but only 55 (64%) received prophylaxis within 1 hour. Overall, there were 12 infections. This infection rate was not statistically different than the reported literature (14% vs 19%, P = .20). The infection rate between those who received antibiotics within 1 hour was not statistically different from those who got it beyond 1 hour (15% vs 13%, P = .98). In conclusion, the use of ceftriaxone as monotherapy for antibiotic prophylaxis in lower extremity type III open fractures is not statistically different than the use of historic prophylactic regimens.
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