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Exploring the role of interleukin 11 in cancer progression, patient survival, and therapeutic insights
Mahsa Hassani1, Mohammad Mahdevar2,3, Maryam Peymani4
1Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Molecular Biology Reports
|March 29, 2024
Summary
Interleukin (IL)-11 gene expression is elevated in 13 cancers, correlating with poor survival and metastasis. This cytokine shows potential as a prognostic biomarker for early cancer detection and treatment resistance.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Interleukin (IL)-11, a cytokine, exhibits oncogenic properties in various cancers.
- IL-11's role in cancer progression, including survival and drug resistance, requires comprehensive analysis.
Purpose of the Study:
- To investigate IL-11 expression across 13 prevalent cancers using TCGA data.
- To evaluate the association of IL-11 with patient survival, drug resistance, and metastasis.
- To explore IL-11's involvement in inflammation pathways.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) database for in-silico analysis of IL-11 expression and survival.
- Employed RT-qPCR to validate IL-11 expression in colorectal cancer (CRC) tissues.
- Applied PharmacoGX database for drug sensitivity analysis and co-expression networks for pathway identification.
Main Results:
- IL-11 expression was significantly upregulated in 13 cancers compared to normal tissues.
- Elevated IL-11 levels correlated with increased mortality in bladder, stomach, colorectal, and endometrial cancers.
- IL-11 showed strong co-expression with metastasis and inflammation-related genes, indicating potential as a biomarker.
Conclusions:
- Altered IL-11 gene expression is linked to prognosis and mortality in multiple cancers.
- IL-11 serves as a potential prognostic biomarker, particularly in colorectal cancer (CRC).
- IL-11's role in cancer progression highlights its significance in therapeutic strategies.
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