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Updated: Jun 29, 2025
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic
Agniete Kampaite1,2, Rebecka Gustafsson1, Elizabeth N York1,2,3
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Plos One
|March 29, 2024
Summary
Brain connectivity changes are linked to fatigue and depression in multiple sclerosis (MS). Abnormalities in cortico-limbic and cortico-thalamic-basal-ganglial networks may underlie these debilitating symptoms in people with relapsing-remitting MS.
Area of Science:
- Neuroscience
- Radiology
- Psychiatry
Background:
- Multiple Sclerosis (MS) is a central nervous system autoimmune disease causing neuroinflammation and neurodegeneration.
- Fatigue and depression are prevalent, intertwined symptoms significantly impacting quality of life for people with relapsing-remitting MS (pwRRMS).
- Understanding the neural underpinnings of these symptoms is crucial for developing targeted interventions.
Conclusions:
- Structural and functional connectivity changes in specific brain networks may underlie fatigue and depression in pwRRMS.
- Current findings are inconclusive, likely due to study heterogeneity and limitations.
- Further research employing advanced MRI techniques and standardized measures is needed to clarify the precise neural substrates of these symptoms.
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