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Updated: Jun 29, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Exploring the Chemical Space Accessed by Chiral Pool Terpenes. The (-)-Caryophyllene Oxide Paradigm
Theodora Athanasiadou1, Georgia G Bagkavou1, Polymnia Karagianni1
1Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
Abstract:
Terpenes represent a flourishing source of structural motifs that can be converted into several more complex architectures. Realization of such transformations in a concise and efficient manner adds great value to the starting material. Herein, we study the case of (-)-caryophyllene oxide and convert it into natural sesquiterpenoids (rumphellolide K, rumphellaone A, and antipacid A), thus expanding the chemical space accessed by its privilege structure. Our semisyntheses are short and rely on reagent-dictated stereo- and chemoselectivity.
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